How 'mind-controlled' bionic devices could help quadriplegics walk

The brain implant sends signals to anything from a bionic prosthetic limb, to a full body ‘exoskeleton’

The development of “mind-controlled” bionic devices moved another step closer today with the publication of a Nature Biotechnology paper describing how a tiny, 3cm-long stent containing 12 electrodes could one day help people living with spinal cord injury to walk with the power of thought.

The device, called the “stentrode”, is inserted into the jugular vein in the neck and pushed up the vein until it reaches the brain’s motor cortex, which is responsible for muscle activity.

I’ve been part of the 39-person team developing and testing the device, and we’re now planning a clinical trial next year in Victoria.

How does it work?

The stentrode’s position, alongside the motor cortex, allows it to receive neural signals that initiate movement. It sends those signals down 12 microleads into a computer interface.


 Get The Latest By Email

Weekly Magazine Daily Inspiration

The University of Melbourne. Source

Here, the signals are translated into information that could manipulate anything from a bionic prosthetic limb to a full body exoskeleton, a transformer-type external skeleton.

The work builds on previous research, which in 2002 found monkeys could move a computer cursor with the power of thought. This showed it was theoretically possible to control a bionic limb using thought alone.

Next, researchers used electrode devices, such as the Utah electrode array, and surgically implanted them just below the skull into the cortex in humans. These devices produced amazing results, including the ability for paralysed patients to operate a remote bionic limb, completely separated from the body, and to take a sip of coffee. These devices are still being developed by a company called BrainGate.

However, insertion of these devices requires major brain surgery that carries risks of infection, and immune rejection. Surgically implanted electrode arrays can also cause brain inflammation and suffer signal quality degradation over six months to a year.

The stentrode aims to overcome these problems. By sitting inside the brain’s vasculature, the stentrode becomes incorporated into the vessel wall, shielding it from the brain immune cells. Our preclinical studies show that the brain signals the stentrode pick up actually become cleaner and stronger with time as this blood vessel incorporation takes place.

Next step: implanting patients

The first patients to receive the stentrode implants will be people who have suffered a spinal injury and ended up with quadriplegia.

Before receiving the implant, patients will undergo functional MRI scanning. They will be asked to imagine moving their arm left and right, up and down, and to imagine moving their hand toward targets on a computer screen.

This will produce a virtual map of the motor cortex the surgeons can aim for during the stentrode implantation surgery, to ensure the device overlies the appropriate region of the motor cortex.

Then the patient’s own brain will begin a learning paradigm, very similar to learning to play an instrument, or a new motor skill. Neurons in the motor cortex will fire in response to a patient’s thought, which will then be translated into a movement of a cursor, bionic limb, or exoskeleton.

Initially those movements will be jerky, uncoordinated and produce the incorrect outcome. But through a process of trial and error, the brain’s neuroplastic properties will allow it to refine the neural activity, eventually allowing coordinated activities such as drinking a coffee, or walking with the aid of an exoskeleton.

Other possible uses

The highly branched vascular system of the brain means the stentrode could potentially be deposited in other vessels to treat a variety of illnesses.

It has the potential to predict epileptic seizures, for instance, if placed in the brain region that gives rise to the seizures. The brain’s neural activity changes in predictable ways before the onset of a seizure. The stentrode could pick up these tell-tale warning signals, alerting the patient to cease any activities which would put them or others in danger, such as driving or swimming.

The stentrode could also be used as a neurostimulation device. Current therapies for Parkinson’s disease include deep-brain stimulation (DBS) to release the dopamine required for smooth, coordinated movements. Using the stentrode as an alternative stimulator would alleviate the risks of implanting stimulators deep into the brain.

The device could also assist people with motor neuron disease (MND) who are robbed of the ability to move, talk, eat and eventually breathe. At the stage where people lose the ability to communicate, the stentrode could be used to provide an interface for people to control a computer. This could give them precious months or years where they can continue to communicate with their loved ones.

The stentrode’s first in-human clinical trials are scheduled for 2017. Provided that we see the anticipated results, we hope that a commercially available version of the technology would be available in the first half of the 2020s.

In the meantime, one aim is to add more electrodes, allowing finer control for paralysed patients to not only walk again, but gain fine finger movements. Could we one day see a “paralysed” violin virtuoso? We can try.

Enclosures

  1. ^ ()

About The Author

Clive May, Professor of Neurophysiology, Florey Institute of Neuroscience and Mental Health

Appeared On The Conversation

AVAILABLE LANGUAGES

English Afrikaans Arabic Chinese (Simplified) Chinese (Traditional) Danish Dutch Filipino Finnish French German Greek Hebrew Hindi Hungarian Indonesian Italian Japanese Korean Malay Norwegian Persian Polish Portuguese Romanian Russian Spanish Swahili Swedish Thai Turkish Ukrainian Urdu Vietnamese

follow InnerSelf on

facebook icontwitter iconyoutube iconinstagram iconpintrest iconrss icon

 Get The Latest By Email

Weekly Magazine Daily Inspiration

Friday, 14 May 2021 08:30

Fertility has declined in most industrialised countries. While the causes are largely unknown, a number of factors may contribute to declining fertility rates, including the age...

Tuesday, 04 May 2021 08:32

Cognitive motor training helps in the fight against Alzheimer’s and dementia, according to new research.

Saturday, 03 April 2021 08:08

Coffee, green tea and other caffeinated drinks are a popular way to start the morning. Not only does it give many people a much-needed boost, but caffeine can also help when it comes to fitness.

Wednesday, 28 April 2021 08:51

Insects are attracted to landscapes where flowering plants of the same species are grouped together and create big blocks of color, according to new research.

Wednesday, 28 April 2021 08:57

Replenishing antioxidants in the body may help protect against oxidative stress and lower the risk of cancer

Wednesday, 05 May 2021 08:15

While our immune system and antibiotics both do a great job of helping us fight life-threatening infections, the emergence of antibiotic resistance is quickly making it more difficult to cure...

New Attitudes - New Possibilities

InnerSelf.comClimateImpactNews.com | InnerPower.net
MightyNatural.com | WholisticPolitics.com | InnerSelf Market
Copyright ©1985 - 2021 InnerSelf Publications. All Rights Reserved.